Nanocrystal is widely applied to improve the dissolution of poorly water-soluble drugs.We aimed to prepare meloxicam (MLX) nanocrystals using the bead mill method, followed by high-pressure homogenization (HPH).Simple drying at room temperature (RD), vacuum-drying (VD), and freeze-drying (FD) using mannitol or trehalose as a cryoprotectant were app
Boerhaave Syndrome in an Elderly Man
Boerhaave syndrome is rare, has an non-specific clinical presentation and most commonly develops after persistent vomiting.Septic shock dominates the clinical picture as a result of Shorts extensive infection of the mediastinum and pleural and abdominal cavities.The current management of Boerhaave syndrome includes conservative, endoscopic and surg
Managing Fungal Infections in Cystic Fibrosis Patients: Challenges in Clinical Practice
Lauren C Magee,1 Mariam Louis,2 Vaneeza Khan,3 Lavender Micalo,3 Nauman Chaudary3 1Department of Pharmacy, Virginia Commonwealth University Health System, Richmond, VA, USA; 2Department of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Jacksonville, FL, CURL CARE SHAMPOO USA; 3Division of Pulmonary Disease and Critical Care Med
Small Vessel Detection Based on Adaptive Dual-Polarimetric Feature Fusion and Sea–Land Segmentation in SAR Images
Detection of small sea vessels in synthetic aperture radar (SAR) images has received much attention in recent years because the small vessels have weak scattering intensity and few image pixels.The existing detection network structures are not well adapted to small-scale targets, the polarimetric data are not properly utilized, and the sea–l
Go local: morality and international activism
A step towards constructing an ethics of international activism is proposed by formulating a series of constraints on what would constitute morally permissible agency in the context that involves delivering services abroad, directly or indirectly.Perhaps surprisingly, in this effort the author makes use of the concept of ‘force multiplier&#x